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Contents 1 introduction 2 Competences 2.1 Issue 2.2 Knowledge 2.3 Skills 2.4 Attitude 3 Set-up of the courses 4 Topics (and subtopics) 4.1 Introduction 4.2 Cellular signalling mechanisms at a molecular level 4.3 The use of state of the art techniques for nutrigenomics research 4.4 Model systems 4.5 Nutrition and epidemiology 4.6 Molecular nutrition and health 4.7 Molecular nutrition and disease 4.8 Nutrigenomics research 4.9 Nutrigenomics and society 4.10 Molecular nutrition and Bioethics 4.11 Communication 4.12 Commercialisation 4.13 Practicals 5 Standardisation

introduction

This document is a starting-point to describe the competences (outcome of the learning process) which a graduate from an ‘ideal’ MSc programme in Molecular Nutrition should have. provide a description of knowledge, skills and attitude for a specific domain. One could a ‘NuGO-approved MSc programme’ as a kind of accreditation for Molecular Nutrition programmes. The competences are then a kind of checklist. However, the competences can also serve as a structured way of identifying the issues for which a ‘NuGO-textbook’ is specifically required as these competences can not be properly trained using currently available textbooks. Finally, academic partners that wish to establish an MSc in Molecular Nutrition can take these competences and determine which training (courses, thesis, etc.) is required to bring their BSc-graduates to this level.

Strictly speaking, for obtaining the degree it doesn’t matter how the competences are reached, as long as they are reached. The actual programme could differ from university to university and even between individual students, based among other things on the competences a student will have at the start of the MSc-programme. A student trained in ‘nutrition & dietetics’ will need a different training from a student trained in ‘molecular life sciences with emphasis on nutrition’.

The MSc in Molecular Nutrition will be a 2-year study programme consisting of 120 ECTS , i.e. 60 ECTS/year (1 study week = 40 hrs = 1,5 ECTS). The first year will consist of compulsory and optional courses. During the second year a major thesis (36ECTS) will be conducted at the university (exchanges between NuGO partners will be supported) in combination with an internship (industry, or health institute, 24 ECTS) or a minor thesis (University, 24 ECTS).

Aiming at the training of future molecular nutrition experts:

• PhD students and junior researchers on molecular nutrition at universities, health research-institutes or industrial R&D institutes
• Account managers or category managers of molecular nutrition-related projects and products in industry
• Retrain experienced scientists (classical nutritional, molecular biologists and others) in molecular nutrition.

Competences

(Based on accredited competences from the MSc Nutrition & Health, specialization ‘Molecular nutrition’ at Wageningen University)

The competences are described in terms of:

• issue (compact description of the problem-area)
• core competence(s)
• relevant knowledge
• relevant skills
• relevant attitudes

Issue

The effects of nutrients and other food components on physiological and health status cannot be understood without a detailed knowledge of the basic metabolism of these compounds and their effects at the cellular and molecular level. Core competence Students should master the principles of controlled experiments in in vitro or in vivo model systems (cells, animals, humans) for human nutrition research and the laboratory methods required for this research

Knowledge

• Basic human physiology and energy metabolism
• Metabolism and Physiology of nutrition
• Metabolic and physiologic basis for the daily requirements for macro and micronutrients
• Physiological basis for changes in nutrient requirement during special circumstances: growth, pregnancy, lactation, sports, old age
• Regulation of nutrient physiology and metabolism
• Cellular signalling mechanisms at a molecular level
• Nutrition related diseases
• Molecular mechanism underlying the cause of important (frequently occurring) nutrition-related diseases
• Genetic origin of selected nutrition related diseases: discriminate between mono and polygenetic diseases
• Methods and design-schemes for molecular nutrition research
• The use of state-of-the-art genomics methods
• The use of model systems for human nutrition research
• Social, economic and regulatory issues related to molecular nutrition
• Consumer attitudes to molecular nutrition
• Entrepreneurship?

Skills

• Identify relevant research questions
• Use of different modern biochemical, cellular, molecular biological and physiological laboratory techniques as well as basic laboratory techniques.
• Analyse and structure in an interdisciplinary way problems in the field of metabolism, nutrition and health. Reformulate the problems into scientific questions and contribute to solving the problems
• Entrepreneurial skills

Attitude

• Interested in elucidating the basic mechanisms underlying the relationships between nutrition and human health and disease at the molecular, biochemical and physiological levels
• Interested in model systems (in vitro, in vivo) as well as laboratory techniques
• Having an open-minded, enterprising, attentive, but critical approach to the natural sciences related to nutrition and health, aiming to develop expert knowledge and skills in order to increase knowledge in the biomedical-oriented field of nutrition and health

Set-up of the courses

• Courses are composed of independent modules
• Each module should consist of a combination of the following units:
• Up-to-date theoretical background knowledge provided as a Wiki textbook
• (chapters of) existing textbooks and suitable publications
• Lectures (ppt slides)
• eLearning module to practice knowledge and/or skills
• design of a practical (if relevant)
• Each module will contain a study load of 1,5 ECTS (= 1 week, 35hrs)
• The modules should be made interchangeable between the courses

Topics (and subtopics)

the core program of the MSc on Molecular nutrition

This list is not a ‘limited’ list, other topics can be included in a NuGO MSc as well. Moreover, different programmes can place emphasis on different issues, in part depending on the types of research the students will do during their MSc-thesis.

Introduction

(this knowledge is going to be basic background knowledge for all the other courses together with one or more foundation courses)

• Basic knowledge on molecular biology (DNA, genome, genes, transcription, translation, etc)
• Molecular approaches to nutrition
• Basic human physiology and energy metabolism

Cellular signalling mechanisms at a molecular level

• Transcriptional regulation
• G-protein regulated cellular signalling
• Nuclear receptors
• Orphan receptors
• Epigenetics

The use of state of the art techniques for nutrigenomics research

• Transcriptomics (and epigenomics)
• Proteomics
• Metabolomics
• Statistics
• Bioinformatics
• Systems biology

Model systems

• Yeast
• C. Elegans
• Transgenic and knock-out animals
• Cultured mammalian cells
• Rodent models of nutritional relevance human diseases

Nutrition and epidemiology

• Nutrigenetics
• Polulation genetics
• SNPs
• Personalized diet

Molecular nutrition and health

• Life stage nutrition
• Nutrition and sport

Molecular nutrition and disease

• Obesity
• Diabetes
• Hypertension
• CVD
• Osteoporosis
• Cancer

Hello

Nutrigenomics research

• From complex health problems to simple research questions
• Techniques to be used
• Experimental design
• Data evaluation

Nutrigenomics and society

Molecular nutrition and Bioethics

Communication

• Report and manuscript writing
• Oral presentations
• Discussion techniques

Commercialisation

• Entrepreneurship
• Molecular nutrition in industry

Practicals

A NuGO-MSc graduate will have performed a lot of ‘lab-work’ during his/her MSc-thesis. So in the end the student will have obtained the practical lab-skills. However, in many cases the thesis research can not include all lab-skills. Moreover, it is felt by many that a student should be trained in lab-skills prior to starting with their MSc-thesis labwork. Therefore, it is desirable to include a significant amount of practicals in a NuGO-MSc programme (depending on the amount of training during the BSc). Practicals can of course not be offered through e-learning, although instructions, simulations and protocols can be offered by electronic means. In addition to training lab-skills, practicals very often also serve as a way to illustrate the knowlegde transferred during lectures.

Standardisation

Within the EU, there is much discussion about harmonisation of educational programmes and recognition of degrees. Also the accreditation of programmes at a European level is discussed a lot. Within the scope of the NuGO MSc discussions, the de facto European standards will be used. For the ‘credits’ and ‘grading’, the ECTS (European Credit Transfer and Accumulation System) will be used. As a basis for the description of the competences, the so called Dublin descriptors will be used to define the level of the second cycle (MSc-level)