IgA

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IgA
2D structure for IgA
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Functional Taxonomy
Nutritional Taxonomy
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Authors: L. Pellis
Affiliations: TNO, the Netherlands


Contents

Introduction

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Human Immunoglobulin A (IgA)

Secretory IgA is found in tears, sweat, saliva, milk, and colostrum, and in gastrointestinal and bronchial secretions. It protects the mucosa from bacteria and viruses. The presence of secretory IgA also affects the development of allergic (IgE) reactions to various ingested antigens by binding the antigens and preventing IgE responses. Increased serum IgA is common in patients with skin, gut, respiratory, and renal infections and in ARC/ AIDS. In portal cirrhosis, IgA and sometimes IgG are increased. Deficiency of IgA is found in one in 750 individuals. Absence of this immunoglobulin is also found in ataxia telangiectasia. A significant number of IgA-deficient individuals will have circulating anti-IgA, which can mediate fatal anaphylactoid reactions when sources of immunoglobulin are infused (e.g., blood component therapy).


Rodent Immunoglobulin A (IgA)

Secretory IgA is found in tears, sweat, saliva, milk, and colostrum, and in gastrointestinal and bronchial secretions. It protects the mucosa from bacteria and viruses. The presence of secretory IgA also affects the development of allergic (IgE) reactions to various ingested antigens by binding the antigens and preventing IgE responses. Increased serum IgA is common in animals with skin, gut, respiratory, and renal infections. In portal cirrhosis, IgA is increased.


Biological Function

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IgA is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.


IgA molecule consists of two basic Y-shaped units which are connected together with a joining chain. Each Y-shaped unit consists of four polypeptides chains, two heavy chains and two light chains, each with constant and variable region. The variable region contains the antigen binding site.

Catabolism

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Diseases / Conditions Related to Nutrition

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Associated decreased protein/metabolite profile

Associated increased protein/metabolite profile

Other (Monogenic) Disorders

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Nutritional Information

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Drivers for biological variation

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Vulnerable groups

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Other resources

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Links

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immunoglobulines Britannica Encyclopedia


IGHA2, IgA CONSTANT HEAVY CHAIN 2 OMIM UniProtKB

IGHA1, IgA CONSTANT HEAVY CHAIN 1 OMIM UniProtKB

IGJ, Immunoglobulin J chain, joining chain UniProtKB

IGHV, IMMUNOGLOBULIN HEAVY CHAIN VARIABLE GENE CLUSTER, IGHV gene cluster OMIM

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